{"id":43,"date":"2014-07-14T18:59:10","date_gmt":"2014-07-14T18:59:10","guid":{"rendered":"http:\/\/140.120.203.75\/wordpress\/?page_id=43"},"modified":"2026-05-28T13:58:50","modified_gmt":"2026-05-28T13:58:50","slug":"collaborations","status":"publish","type":"page","link":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/","title":{"rendered":"Welcome"},"content":{"rendered":"\n
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About the Lab<\/h2>\n\n\n\n

Led by Prof. Ying-Tsong Chen, the Microbial Genomics Laboratory at National Chung Hsing University studies how microorganisms evolve, spread, and influence human, animal, and environmental health. We combine genome sequencing, bioinformatics, and microbiology to investigate important questions in infectious diseases, microbial evolution, and public health.<\/p>\n\n\n\n

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\u5fae\u751f\u7269\u57fa\u56e0\u9ad4\u7814\u7a76\u5ba4\u7531\u9673\u76c8\u7481\u6559\u6388\u4e3b\u6301\uff0c\u96b8\u5c6c\u65bc\u570b\u7acb\u4e2d\u8208\u5927\u5b78\u57fa\u56e0\u9ad4\u66a8\u751f\u7269\u8cc7\u8a0a\u5b78\u7814\u7a76\u6240\uff0c\u4e3b\u8981\u63a2\u8a0e\u5fae\u751f\u7269\u5982\u4f55\u6f14\u5316\u3001\u50b3\u64ad\uff0c\u4ee5\u53ca\u5176\u5c0d\u4eba\u985e\u3001\u52d5\u7269\u8207\u74b0\u5883\u5065\u5eb7\u7684\u5f71\u97ff\u3002\u7814\u7a76\u5ba4\u7d50\u5408\u57fa\u56e0\u9ad4\u5b9a\u5e8f\u3001\u751f\u7269\u8cc7\u8a0a\u5206\u6790\u8207\u5fae\u751f\u7269\u5b78\u65b9\u6cd5\uff0c\u7814\u7a76\u611f\u67d3\u75c7\u3001\u5fae\u751f\u7269\u6f14\u5316\uff0c\u4ee5\u53ca\u516c\u5171\u885b\u751f\u4e2d\u7684\u91cd\u8981\u79d1\u5b78\u554f\u984c\u3002<\/p>\n<\/div>

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Research Themes\uff5c\u7814\u7a76\u4e3b\u984c<\/h2>\n\n\n\n
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Antimicrobial Resistance and Mobile Genetic Elements<\/h3>\n\n\n\n

\u6297\u751f\u7d20\u6297\u85e5\u6027\u8207\u53ef\u79fb\u52d5\u907a\u50b3\u56e0\u5b50<\/p>\n\n\n\n

Mobile genetic elements, including plasmids, integrative elements, and resistance islands, play a central role in the emergence and spread of antimicrobial resistance. In this research area, we investigate the evolution, transmission, and fitness effects of transferable resistance determinants in clinically important bacteria.<\/p>\n<\/div><\/div>\n\n\n\n

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Emerging Pathogens and Outbreak Genomics<\/h3>\n\n\n\n

\u65b0\u8208\u75c5\u539f\u9ad4\u8207\u75ab\u60c5\u57fa\u56e0\u9ad4\u5b78<\/p>\n\n\n\n

Using whole-genome sequencing and comparative genomics, we study the emergence, transmission, and persistence of clinically important bacterial pathogens. Research in this area supports outbreak investigation, genomic surveillance, and the tracking of newly emerging high-risk lineages.<\/p>\n<\/div>

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Host\u2013Microbe Interactions and Functional Regulation<\/h3>\n\n\n\n

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This research theme examines how bacteria regulate virulence, stress responses, and host adaptation through transcriptional networks, genome plasticity, and mobile regulators. We aim to uncover molecular mechanisms that shape pathogen behavior in host-associated environments.<\/p>\n<\/div><\/div>\n\n\n\n

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Symbiotic Microbes and Vector Control Genomics<\/strong><\/h3>\n\n\n\n

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Our group develops adaptive sequencing methods to obtain complete genomes of endosymbiotic bacteria such as Wolbachia from complex mosquito-associated samples. Studies in this area enable genomic analyses of difficult-to-isolate symbionts and support applications in mosquito biology, disease control, and microbial ecology.<\/p>\n<\/div>

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Training & Opportunities\uff5c\u5b78\u7fd2\u8207\u767c\u5c55\u6a5f\u6703<\/h2>\n\n\n\n
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Students in our laboratory receive interdisciplinary training in genomics, bioinformatics, microbiology, scientific writing, and research design. We welcome students from biology, medicine, agriculture, data science, and related fields. \u7814\u7a76\u5ba4\u63d0\u4f9b\u57fa\u56e0\u9ad4\u5b78\u3001\u751f\u7269\u8cc7\u8a0a\u3001\u5fae\u751f\u7269\u5b78\u3001\u79d1\u5b78\u5beb\u4f5c\u8207\u7814\u7a76\u8a2d\u8a08\u7b49\u8de8\u9818\u57df\u8a13\u7df4\uff0c\u6b61\u8fce\u751f\u547d\u79d1\u5b78\u3001\u91ab\u5b78\u3001\u8fb2\u696d\u3001\u8cc7\u6599\u79d1\u5b78\u53ca\u76f8\u95dc\u80cc\u666f\u5b78\u751f\u52a0\u5165\u3002<\/p>\n\n\n\n

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Research Highlights\uff5c\u904e\u53bb\u7814\u7a76\u6210\u679c<\/h2>\n\n\n\n
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\"Genotoxic\u00a0Klebsiella
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Genotoxic\u00a0Klebsiella pneumoniae\u00a0in Taiwan<\/a><\/h6><\/div><\/div>
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\"From
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From Idea to Genome: Reconstructing Wolbachia Using Adaptive Sampling<\/a><\/h6><\/div><\/div>
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\u7576\u7d30\u83cc\u5077\u4f86\u7684\u4e0d\u53ea\u662f\u6297\u85e5\u57fa\u56e0<\/a><\/h6><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

About the Lab Led by Prof. Ying-Tsong Chen, the Microbial Genomics Laboratory at National Chung Hsing University studies how microorganisms<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"colormag_page_container_layout":"default_layout","colormag_page_sidebar_layout":"default_layout","footnotes":""},"class_list":["post-43","page","type-page","status-publish","hentry"],"magazineBlocksPostFeaturedMedia":{"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"colormag-highlighted-post":false,"colormag-featured-post-medium":false,"colormag-featured-post-small":false,"colormag-featured-image":false,"colormag-default-news":false,"colormag-featured-image-large":false},"magazineBlocksPostAuthor":{"name":"onion","avatar":"https:\/\/secure.gravatar.com\/avatar\/a596197721c6296d27446d1377ed931e199d7d76ae4dedbebf95195b579de271?s=96&d=mm&r=g"},"magazineBlocksPostCommentsNumber":false,"magazineBlocksPostExcerpt":"About the Lab Led by Prof. Ying-Tsong Chen, the Microbial Genomics Laboratory at National Chung Hsing University studies how microorganisms","magazineBlocksPostCategories":[],"magazineBlocksPostViewCount":0,"magazineBlocksPostReadTime":2,"_links":{"self":[{"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/pages\/43","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=43"}],"version-history":[{"count":93,"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/pages\/43\/revisions"}],"predecessor-version":[{"id":2507,"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/pages\/43\/revisions\/2507"}],"wp:attachment":[{"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=43"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}