{"id":6,"date":"2023-08-01T14:43:46","date_gmt":"2023-08-01T14:43:46","guid":{"rendered":"http:\/\/140.120.203.75\/wordpress\/?page_id=6"},"modified":"2026-04-28T04:03:19","modified_gmt":"2026-04-28T04:03:19","slug":"principal-investigator","status":"publish","type":"page","link":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/?page_id=6","title":{"rendered":"Principle Investigator"},"content":{"rendered":"\n
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\u7814\u7a76\u5ba4\u4e3b\u6301\u4eba<\/p>\n\n\n\n

Ying-Tsong Chen \u9673\u76c8\u7481 <\/h2>\n\n\n\n

\u570b\u7acb\u4e2d\u8208\u5927\u5b78 \u751f\u547d\u79d1\u5b78\u9662 \u57fa\u56e0\u9ad4\u66a8\u751f\u7269\u8cc7\u8a0a\u7814\u7a76\u6240 \u6559\u6388 (2022-)<\/p>\n\n\n\n

Professor, Graduate Institute of Genomics and Bioinformatics<\/a>, College of Life Sciences<\/a>, National Chung Hsing University<\/a>, Taiwan<\/p>\n\n\n\n

\u570b\u5bb6\u885b\u751f\u7814\u7a76\u9662 \u5206\u5b50\u8207\u57fa\u56e0\u91ab\u5b78\u7814\u7a76\u6240 \u517c\u4efb\u7814\u7a76\u54e1(2023-)<\/p>\n\n\n\n

Adjunct Investigator, Institute of Molecular and Genomic Medicine<\/a>, National Health Research Institutes<\/a>, Taiwan<\/p>\n\n\n\n

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onion@nchu.edu.tw<\/p>\n\n\n\n

Google Scholar<\/a> \u30fb Facebook<\/a> \u30fbScopus<\/a><\/p>\n\n\n\n

\"ORCIDhttps:\/\/orcid.org\/0000-0003-1337-4127<\/a><\/div>\n\n\n\n
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\u6211\u76f8\u4fe1\u597d\u7684\u7814\u7a76\u4f86\u81ea\u597d\u5947\u5fc3\u3001\u624e\u5be6\u8a13\u7df4\u8207\u9577\u671f\u6295\u5165\u3002
Good science begins with curiosity, grows through discipline, and succeeds through persistence.<\/p>\n<\/blockquote>\n<\/div>

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About Professor Chen<\/h2>\n\n\n\n
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Prof. Ying-Tsong Chen<\/strong> is a faculty member at the Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University.<\/p>\n\n\n\n

His research centers on microbial genomics, antimicrobial resistance, pathogen evolution, and host-associated microbes. By integrating genome sequencing, bioinformatics, and molecular microbiology, his group investigates how microbes acquire resistance, virulence, and adaptive traits through genomic change and mobile genetic elements.<\/p>\n\n\n\n

Recent interests include outbreak genomics of emerging pathogens, One Health microbiology, and genomic applications of endosymbionts such as Wolbachia.<\/p>\n\n\n\n

Prof. Chen is committed to mentoring students through rigorous research training, interdisciplinary thinking, and problem-driven scientific inquiry.<\/p>\n\n\n\n

\u9673\u6559\u6388\u73fe\u4efb\u570b\u7acb\u4e2d\u8208\u5927\u5b78\u751f\u547d\u79d1\u5b78\u9662\u57fa\u56e0\u9ad4\u66a8\u751f\u7269\u8cc7\u8a0a\u7814\u7a76\u6240\u6559\u5e2b\uff0c\u7814\u7a76\u9818\u57df\u6db5\u84cb\u5fae\u751f\u7269\u57fa\u56e0\u9ad4\u5b78\u3001\u6297\u751f\u7d20\u6297\u85e5\u6027\u3001\u75c5\u539f\u9ad4\u6f14\u5316\uff0c\u4ee5\u53ca\u5bbf\u4e3b\u76f8\u95dc\u5fae\u751f\u7269\u3002<\/p>\n\n\n\n

\u7814\u7a76\u5718\u968a\u7d50\u5408\u57fa\u56e0\u9ad4\u5b9a\u5e8f\u3001\u751f\u7269\u8cc7\u8a0a\u5206\u6790\u8207\u5206\u5b50\u5fae\u751f\u7269\u5b78\u65b9\u6cd5\uff0c\u63a2\u8a0e\u5fae\u751f\u7269\u5982\u4f55\u900f\u904e\u57fa\u56e0\u9ad4\u8b8a\u7570\u8207\u53ef\u79fb\u52d5\u907a\u50b3\u56e0\u5b50\u7372\u5f97\u6297\u85e5\u6027\u3001\u81f4\u75c5\u80fd\u529b\u53ca\u74b0\u5883\u9069\u61c9\u7279\u5fb5\u3002<\/p>\n\n\n\n

\u8fd1\u5e74\u7814\u7a76\u65b9\u5411\u5305\u62ec\u65b0\u8208\u75c5\u539f\u9ad4\u7fa4\u805a\u4e8b\u4ef6\u57fa\u56e0\u9ad4\u5206\u6790\u3001One Health \u5fae\u751f\u7269\u5b78\uff0c\u4ee5\u53ca Wolbachia \u7b49\u5171\u751f\u83cc\u4e4b\u57fa\u56e0\u9ad4\u61c9\u7528\u3002<\/p>\n\n\n\n

\u7814\u7a76\u5ba4\u91cd\u8996\u5b78\u751f\u7684\u7814\u7a76\u8a13\u7df4\u8207\u7368\u7acb\u601d\u8003\u80fd\u529b\uff0c\u9f13\u52f5\u8de8\u9818\u57df\u5408\u4f5c\u8207\u5be6\u52d9\u554f\u984c\u5c0e\u5411\u7684\u79d1\u5b78\u63a2\u7d22\uff0c\u6b61\u8fce\u5c0d\u7814\u7a76\u5145\u6eff\u71b1\u5ff1\u7684\u540c\u5b78\u52a0\u5165\u5718\u968a\u3002<\/p>\n<\/div><\/div>\n\n\n\n

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\u6211\u7684\u7814\u7a76\u5de5\u4f5c\uff0c\u5728\u65bc\u9023\u7d50\u5fae\u751f\u7269\u57fa\u56e0\u9ad4\u5b78\u8207\u5be6\u9a57\u5275\u9020\u529b\u3002\u5f88\u591a\u6642\u5019\uff0c\u6211\u6240\u505a\u7684\u662f\u5c0b\u627e\u5404\u7a2e\u9023\u7d50\u2014\u2014\u5206\u5b50\u6a5f\u5236\u8207\u751f\u7269\u610f\u7fa9\u4e4b\u9593\u3001\u6578\u64da\u8207\u7406\u89e3\u4e4b\u9593\uff0c\u4ee5\u53ca\u79d1\u5b78\u8207\u5be6\u8e10\u79d1\u5b78\u7684\u4eba\u4e4b\u9593\u3002

My work bridges microbial genomics and experimental creativity. Much of it is about finding connections\u2014between molecular mechanisms and biological meaning, between data and understanding, and between science and the people who do it. <\/p>\n<\/blockquote>\n\n\n\n

<\/div>\n\n\n\n

Career, Education and Honors<\/h2>\n\n\n\n
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Graduate Institute of Genomics and Bioinformatics, COLS, NCHU
\u570b\u7acb\u4e2d\u8208\u5927\u5b78 \u751f\u547d\u79d1\u5b78\u9662 \u57fa\u56e0\u9ad4\u66a8\u751f\u7269\u8cc7\u8a0a\u7814\u7a76\u6240<\/p>\n\n\n\n

    \n
  • Associate Professor \u526f\u6559\u6388 (2014-2022)<\/li>\n\n\n\n
  • Assistant Professor \u52a9\u7406\u6559\u6388 (2010-2014)<\/li>\n<\/ul>\n\n\n\n

    Institute of Molecular and Genomic Medicine, NHRI
    \u570b\u5bb6\u885b\u751f\u7814\u7a76\u9662 \u5206\u5b50\u8207\u57fa\u56e0\u91ab\u5b78\u7814\u7a76\u6240<\/p>\n\n\n\n

      \n
    • Adjunct Associate Investigator \u517c\u4efb\u526f\u7814\u7a76\u54e1(2019-2023)<\/li>\n\n\n\n
    • Joint Associate Investigator \u5408\u8058\u526f\u7814\u7a76\u54e1(2018-2019)<\/li>\n\n\n\n
    • Joint Assistant Investigator \u5408\u8058\u52a9\u7814\u7a76\u54e1(2011-2017)<\/li>\n\n\n\n
    • PostDoc \u535a\u58eb\u5f8c\u7814\u7a76 (2004-2010)<\/li>\n\n\n\n
    • <\/li>\n<\/ul>\n\n\n\n

      PhD, Department of Biological Science and Technology, National Chiao Tung University
      \u570b\u7acb\u4ea4\u901a\u5927\u5b78 \u751f\u7269\u79d1\u6280\u7cfb \u535a\u58eb (2000-2004)
      MS, Institute of Genetics, National Yang-Ming University
      \u570b\u7acb\u967d\u660e\u5927\u5b78 \u907a\u50b3\u5b78\u7814\u7a76\u6240 \u78a9\u58eb (1994-1996)
      BE, Department of Bioengineering, Tatung Institute of Technology
      \u5927\u540c\u5de5\u5b78\u9662 \u751f\u7269\u5de5\u7a0b\u7cfb \u5b78\u58eb (1990-1994)<\/p>\n\n\n\n

      109\u5e74\u8cc7\u6df1\u512a\u826f\u6559\u5e2b(2020)
      \u751f\u79d1\u9662\u63a8\u85a6\u512a\u8058\u6559\u5e2b(2018)
      \u570b\u7acb\u4e2d\u8208\u5927\u5b78\u512a\u826f\u901a\u8b58\u6559\u5e2b\u734e(2015)
      \u5091\u51fa\u9752\u5e74\u6559\u5e2b\u734e\u52f5(2014)<\/p>\n<\/div>

      \"\"<\/figure><\/div>\n\n\n\n
      \n\n\n\n

      Featured publications<\/h2>\n\n\n\n

      Hypervirulent Klebsiella pneumoniae plasmid pLVPK<\/h4>\n\n\n\n

      Gene<\/em> (2004)
      One of the early complete analyses of a major virulence plasmid, revealing how mobile genetic elements contribute to hypervirulence.<\/p>\n\n\n\n

      \n\n\n\n

      NDM-1 plasmid dissemination in Klebsiella pneumoniae<\/h4>\n\n\n\n

      PLOS ONE<\/em> (2012)
      Showed that carbapenem resistance can spread through epidemic plasmids shared across unrelated bacterial strains.<\/p>\n\n\n\n

      \n\n\n\n

      Elizabethkingia anophelis outbreak from hospital water system<\/h4>\n\n\n\n

      Journal of Hospital Infection<\/em> (2021)
      Identified a persistent hospital water reservoir responsible for a multi-year outbreak using comparative genomics.<\/p>\n\n\n\n

      \n\n\n\n

      RamAp regulator carried by IncHI2 plasmid in Salmonella enterica<\/h4>\n\n\n\n

      Antimicrobial Agents and Chemotherapy<\/em> (2022)
      Discovered a plasmid-borne regulator linking horizontal gene transfer with antimicrobial resistance and virulence control.<\/p>\n\n\n\n

      \n\n\n\n

      Adaptive sampling for Wolbachia genome reconstruction<\/h4>\n\n\n\n

      bioRxiv<\/em> (2026)
      Developed a nanopore sequencing strategy for recovering intracellular symbiont genomes directly from host tissues.<\/p>\n","protected":false},"excerpt":{"rendered":"

      About Professor Chen Prof. Ying-Tsong Chen is a faculty member at the Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University.<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"colormag_page_container_layout":"default_layout","colormag_page_sidebar_layout":"default_layout","footnotes":""},"class_list":["post-6","page","type-page","status-publish","hentry"],"magazineBlocksPostFeaturedMedia":{"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"colormag-highlighted-post":false,"colormag-featured-post-medium":false,"colormag-featured-post-small":false,"colormag-featured-image":false,"colormag-default-news":false,"colormag-featured-image-large":false},"magazineBlocksPostAuthor":{"name":"onion","avatar":"https:\/\/secure.gravatar.com\/avatar\/a596197721c6296d27446d1377ed931e199d7d76ae4dedbebf95195b579de271?s=96&d=mm&r=g"},"magazineBlocksPostCommentsNumber":false,"magazineBlocksPostExcerpt":"About Professor Chen Prof. Ying-Tsong Chen is a faculty member at the Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University.","magazineBlocksPostCategories":[],"magazineBlocksPostViewCount":0,"magazineBlocksPostReadTime":2,"_links":{"self":[{"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/pages\/6","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6"}],"version-history":[{"count":114,"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/pages\/6\/revisions"}],"predecessor-version":[{"id":2370,"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/pages\/6\/revisions\/2370"}],"wp:attachment":[{"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}