{"id":846,"date":"2022-09-14T15:56:44","date_gmt":"2022-09-14T15:56:44","guid":{"rendered":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/?page_id=846"},"modified":"2022-10-11T10:28:36","modified_gmt":"2022-10-11T10:28:36","slug":"klebsiella-pneumoniae","status":"publish","type":"page","link":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/?page_id=846","title":{"rendered":"Klebsiella pneumoniae"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><em>K. pneumoniae<\/em>&nbsp;subsp. pneumoniae&nbsp;1084 chromosome<\/h2>\n\n\n\n<p><em>K. pneumoniae<\/em>&nbsp;1084 is a K1 strain isolated from a diabetic patient with severe bacteremic liver abscess. Complete sequencing and annotation of&nbsp;<em>K. pneumoniae<\/em>&nbsp;1084 was conducted by our group. At the&nbsp;<em>asn<\/em>&nbsp;tRNA loci of the sequenced&nbsp;<em>K. pneumoniae<\/em>&nbsp;1084 genome, we identified a 208-kb genomic island, KPHPI208, of which a region identical to the&nbsp;<em>E. coli pks<\/em>&nbsp;colibactin gene cluster was recognized (<a rel=\"noreferrer noopener\" href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0096292#\" data-type=\"URL\" data-id=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0096292#\" target=\"_blank\">Reference<\/a>). <\/p>\n\n\n\n<p>NCBI Reference Sequence: NC_018522.1<\/p>\n\n\n\n<iframe loading=\"lazy\" id=\"iframe_NCBI\" width=\"1019\" height=\"600\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/projects\/sviewer\/embedded_iframe.html?iframe=iframe_NCBI&amp;id=NC_018522.1&amp;report=graph&amp;tracks=[key:sequence_track,name:Sequence,display_name:Sequence,id:STD649220238,annots:Sequence,ShowLabel:false,ColorGaps:false,shown:true,order:1][key:gene_model_track,name:Genes,display_name:Genes,id:STD3194982005,annots:Unnamed,Options:MergeAll,CDSProductFeats:false,NtRuler:true,AaRuler:true,HighlightMode:2,ShowLabel:true,shown:true,order:5][key:feature_track,name:Repeat region,display_name:Repeat region,id:STD3463812800,subkey:repeat_region,annots:Unnamed,shown:true,order:6]&amp;assm_context=GCF_000294365.1&amp;v=1731660:1762219&amp;c=99CC00&amp;select=gi|402778297-001aa68d-001aa96b-0101-9ad1d158-ffea8d58&amp;slim=0&amp;appname=no_appname\" onload=\"if(!window._SViFrame){_SViFrame=true;window.addEventListener('message',function(e){if(e.origin=='https:\/\/www.ncbi.nlm.nih.gov' &amp;&amp; !isNaN(e.data.h))document.getElementById(e.data.f).height=parseInt(e.data.h);});}\">\n<\/iframe>\n\n\n\n<h2 class=\"wp-block-heading\">\u95dc\u65bc\u9019\u500b\u7d30\u83cc\u7684\u6545\u4e8b<\/h2>\n\n\n\n<p>\u514b\u96f7\u767d\u6c0f\u80ba\u708e\u83cc(Klebsiella pneumoniae)\u662f\u4eba\u985e\u8eab\u4e0a\u5e38\u898b\u7684\u8178\u5167\u83cc\uff0c\u4f46\u5b83\u4e5f\u80fd\u4f3a\u6a5f\u9020\u6210\u80ba\u708e\u3001\u50b7\u53e3\u611f\u67d3\u3001\u5c3f\u9053\u611f\u67d3\u7b49\u75be\u75c5\uff0c\u7279\u5225\u662f\u7d93\u5e38\u9020\u6210\u5728\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u809d\u81bf\u760d\u3002\u904e\u53bb\u5728\u53f0\u7063\u6709\u4e0d\u5c11\u5927\u898f\u6a21\u7684\u81e8\u5e8a\u7814\u7a76\u767c\u73fe\uff0c\u514b\u96f7\u767d\u6c0f\u80ba\u708e\u83cc\u9020\u6210\u7684\u809d\u81bf\u760d(KLA)\u8207\u5927\u8178\u76f4\u8178\u764c(CRC)\u7684\u767c\u751f\u6709\u8457\u986f\u8457\u7684\u76f8\u95dc\u6027\u3002\u4f46\u70ba\u4ec0\u9ebc\u9019\u6a23\u7684\u7d30\u83cc\u611f\u67d3\u6703\u6709\u8207\u764c\u75c7\u7684\u95dc\u806f\u5462\uff1f<br>\u514b\u96f7\u767d\u6c0f\u80ba\u708e\u83cc\u53ef\u5206\u6210\u8d85\u904e80\u7a2e\u4e0d\u540c\u7684K\u578b(K types)\uff0c\u5176\u4e2dK1\u8207K2\u578b\u662f\u53f0\u7063\u6700\u5e38\u898b\u7684\u3002\u904e\u53bb\uff0c\u6211\u5011\u5728\u8207\u4e2d\u5c71\u91ab\u5927\u7684\u5408\u4f5c\u7814\u7a76\u4e2d\uff0c\u610f\u5916\u5730\u5f9e\u4e00\u682a\u4ee3\u865f\u70ba1084\u7684\u672c\u571fK1\u578b\u809d\u81bf\u760d\u81e8\u5e8a\u5206\u96e2\u682a\u7684\u5168\u57fa\u56e0\u9ad4\u5b9a\u5e8f\u5206\u6790\u4e2d\uff0c\u7387\u5148\u767c\u73fe\u4e86\u4e00\u500b\u651c\u5e36\u4e86\u591a\u7a2e\u81f4\u75c5\u57fa\u56e0\u7684\u57fa\u56e0\u5c0f\u5cf6(genomic island)\u5340\u57df\u3002\u9019\u500b\u57fa\u56e0\u9ad4\u5340\u57df\u4e2d\u6709\u4e00\u6bb5\u7d0450-kb\u9577\u7684\u57fa\u56e0\u5c0f\u5cf6\u6a21\u7d44\uff0c\u8207\u5927\u8178\u687f\u83ccB2\u7fa4\u7684\u4e00\u6bb5\u8ca0\u8cac\u57fa\u56e0\u6bd2\u6027(genotoxicity)\u7684\u6838\u9178\u5e8f\u5217\u9ad8\u5ea6\u76f8\u4f3c\u3002\u904e\u53bb\u7814\u7a76\u66fe\u6307\u51fa\uff0c\u5e36\u6709\u9019\u7a2e\u57fa\u56e0\u6bd2\u6027\u7684\u5927\u8178\u687f\u83cc\u611f\u67d3\u80fd\u9020\u6210\u5bbf\u4e3b\u7d30\u80deDNA\u7684\u65b7\u88c2\u3002\u9019\u7a2e\u57fa\u56e0\u6bd2\u6027\u5c0d\u5bbf\u4e3bDNA\u7684\u7834\u58de\u6975\u53ef\u80fd\u4e5f\u76f4\u63a5\u6216\u9593\u63a5\u5730\u63d0\u9ad8\u5bbf\u4e3b\u7d30\u80de\u764c\u5316\u7684\u98a8\u96aa\u3002\u6211\u5011\u5f9e\u570b\u885b\u9662\u6536\u96c6\u81ea\u5168\u53f0\u7684\u514b\u96f7\u767d\u6c0f\u80ba\u708e\u83cc\u81e8\u5e8a\u5206\u96e2\u682a\u4e2d\u7be9\u6aa2\uff0c\u767c\u73fe\u9019\u500b\u57fa\u56e0\u6bd2\u6027\u682a\u6709\u76f8\u7576\u9ad8\u7684\u76db\u884c\u7387\uff0c\u6bd4\u4f8b\u660e\u986f\u9ad8\u65bc\u570b\u5916\u7684\u6578\u64da\u3002\u6211\u5011\u7684\u5206\u6790\u767c\u73fe\uff0c\u9019\u4e9b\u57fa\u56e0\u6bd2\u6027\u8207\u53f0\u7063\u76db\u884c\u7684K\u578b\u76f8\u95dc\u3002\u57fa\u56e0\u578b\u5206\u6790\u767c\u73fe\u9019\u4e9b\u57fa\u56e0\u6bd2\u6027\u682a\u6975\u53ef\u80fd\u5206\u5225\u6e90\u81ea\u6578\u500b\u9ad8\u6bd2\u6027\u7d14\u7cfb(clones)\u3002\u6211\u5011\u5728\u9019\u4e00\u4e3b\u984c\u7684\u7814\u7a76\u81ea2012\u5e74\u8d77\u5df2\u7d93\u9678\u7e8c\u767c\u8868\u4e86\u56db\u7bc7\u7814\u7a76\u8ad6\u6587\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u9019\u500b\u7814\u7a76\u62ab\u9732\u4e86\u53f0\u7063\u514b\u96f7\u767d\u6c0f\u80ba\u708e\u83cc\u7684\u57fa\u56e0\u6bd2\u6027\uff0c\u4e5f\u70ba\u570b\u5167\u809d\u81bf\u760d\u8207\u5927\u8178\u76f4\u8178\u764c\u9019\u5169\u500b\u91cd\u8981\u75be\u75c5\u9593\u7684\u806f\u7d50\u63d0\u4f9b\u4e86\u4e00\u500b\u5f88\u6709\u8da3\u7684\u8aaa\u6cd5\u3002<\/p><\/blockquote>\n\n\n\n<p>\u7d30\u83cc\u8207\u4eba\u985e\u5065\u5eb7\u606f\u606f\u76f8\u95dc\uff0c\u7136\u800c\u76ee\u524d\u8f03\u5ee3\u70ba\u4eba\u77e5\u7684\u7d30\u83cc\u611f\u67d3\u8207\u764c\u75c7\u9593\u7684\u95dc\u4fc2\uff0c\u50c5\u6709\u5e7d\u9580\u87ba\u65cb\u687f\u83cc\u8207\u80c3\u764c\u7684\u4f8b\u5b50\u3002\u5927\u8178\u76f4\u8178\u764c\u662f\u8fd1\u5e74\u87ec\u806f\u53f0\u7063\u6392\u540d\u7b2c\u4e00\u7684\u764c\u75c7\u3002\u4e0d\u540c\u65bc\u4e73\u764c\u7b49\u5728\u6b50\u7f8e\u570b\u5bb6\u5e38\u898b\u7684\u764c\u75c7\uff0c\u5927\u8178\u76f4\u8178\u764c\u7684\u98a8\u96aa\u56e0\u5b50\u591a\u662f\u5916\u5728\u56e0\u7d20\u9020\u6210\uff0c\u800c\u975e\u4f86\u81ea\u4eba\u9ad4\u65e2\u6709\u7684\u57fa\u56e0\u7f3a\u9677\u3002\u627e\u51fa\u9019\u4e9b\u5916\u5728\u7684\u98a8\u96aa\u56e0\u5b50\u56e0\u6b64\u8b8a\u5f97\u975e\u5e38\u91cd\u8981\u3002\u5982\u4eca\u9019\u500b\u57fa\u56e0\u6bd2\u6027\u5df2\u7d93\u6210\u70ba\u5168\u4e16\u754c\u8a8d\u5b9a\u514b\u96f7\u767d\u6c0f\u80ba\u708e\u83cc\u8d85\u9ad8\u6bd2\u6027\u682a\u7684\u5b9a\u7fa9\uff0c\u9019\u4e00\u7cfb\u5217\u7684\u7814\u7a76\u8ad6\u6587\u5df2\u88abPubMed\u671f\u520a\u5f15\u7528\u4e86\u8d85\u904e100\u6b21\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>K. pneumoniae&nbsp;subsp. pneumoniae&nbsp;1084 chromosome K. pneumoniae&nbsp;1084 is a K1 strain isolated from a diabetic patient with severe bacteremic liver abscess.<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"colormag_page_container_layout":"no_sidebar_full_width","colormag_page_sidebar_layout":"no_sidebar","footnotes":""},"class_list":["post-846","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/pages\/846","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=846"}],"version-history":[{"count":7,"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/pages\/846\/revisions"}],"predecessor-version":[{"id":892,"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/pages\/846\/revisions\/892"}],"wp:attachment":[{"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=846"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}