methicillin-resistant Staphylococcus aureus<\/em> \u7684\u7e2e\u5beb\uff0c\u4e2d\u6587\u5e38\u7ffb\u4f5c\u300c\u6297\u7532\u6c27\u897f\u6797\u91d1\u9ec3\u8272\u8461\u8404\u7403\u83cc\u300d\u3002\u91d1\u9ec3\u8272\u8461\u8404\u7403\u83cc\u672c\u4f86\u5c31\u662f\u4e00\u7a2e\u5f88\u5e38\u898b\u7684\u7d30\u83cc\uff0c\u4e0d\u5c11\u4eba\u76ae\u819a\u6216\u9f3b\u8154\u4e0a\u90fd\u5e36\u8457\u5b83\uff0c\u591a\u534a\u4e0d\u6703\u51fa\u554f\u984c\uff0c\u4f46\u5728\u7279\u5b9a\u60c5\u6cc1\u4e0b\uff0c\u5b83\u4e5f\u53ef\u80fd\u5f15\u8d77\u76ae\u819a\u611f\u67d3\u3001\u80ba\u708e\uff0c\u751a\u81f3\u8840\u6db2\u611f\u67d3\u3002\u6240\u8b02 MRSA\uff0c\u6307\u7684\u662f\u5176\u4e2d\u4e00\u7fa4\u5c0d\u591a\u7a2e\u5e38\u7528\u6297\u751f\u7d20\u5177\u6709\u6297\u85e5\u6027\u7684\u83cc\u682a\uff0c\u56e0\u6b64\u5728\u81e8\u5e8a\u6cbb\u7642\u4e0a\u7279\u5225\u68d8\u624b\u3002<\/p>\n\n\n\n\u96a8\u8457\u57fa\u56e0\u9ad4\u6280\u8853\u7684\u9032\u5c55\uff0c\u7814\u7a76\u8005\u9010\u6f38\u767c\u73fe\uff0cMRSA \u4e26\u4e0d\u662f\u55ae\u4e00\u4f86\u6e90\u7684\u7d30\u83cc\uff0c\u800c\u662f\u7531\u8a31\u591a\u5f7c\u6b64\u6709\u89aa\u7de3\u95dc\u4fc2\u3001\u4f46\u751f\u614b\u80cc\u666f\u4e0d\u540c\u7684\u65cf\u7fa4\u6240\u7d44\u6210\u3002\u70ba\u4e86\u63cf\u8ff0\u9019\u4e9b\u89aa\u7de3\u95dc\u4fc2\uff0c\u5e38\u6703\u4f7f\u7528\u300cclonal complex\uff08\u7c21\u7a31 CC\uff09\u300d\u9019\u6a23\u7684\u5206\u985e\u65b9\u5f0f\u3002\u7c21\u55ae\u4f86\u8aaa\uff0cCC \u6307\u7684\u662f\u4e00\u7fa4\u5728\u57fa\u56e0\u9ad4\u7684\u57fa\u672c\u7d50\u69cb\u4e0a\u5f7c\u6b64\u76f8\u8fd1\u3001\u4f86\u81ea\u540c\u4e00\u6f14\u5316\u652f\u7cfb\u7684\u83cc\u682a\u96c6\u5408\u3002\u50cf CC398\uff0c\u5c31\u662f MRSA \u5bb6\u65cf\u4e2d\u7684\u5176\u4e2d\u4e00\u652f\u3002<\/p>\n\n\n\n
\u4e5f\u6b63\u56e0\u70ba\u9019\u6a23\uff0c\u7576\u6211\u5011\u5728\u8ac7 CC398 \u6642\uff0c\u5176\u5be6\u4e0d\u662f\u5728\u8ac7\u300c\u4e00\u682a\u7d30\u83cc\u300d\uff0c\u800c\u662f\u5728\u8ac7\u4e00\u6574\u500b\u5177\u6709\u5171\u540c\u6f14\u5316\u80cc\u666f\u3001\u4f46\u53ef\u80fd\u5df2\u7d93\u5206\u5316\u51fa\u4e0d\u540c\u751f\u614b\u578b\u614b\u7684\u65cf\u7fa4\u3002<\/p>\n\n\n\n
\u5728\u9019\u4e9b\u4e0d\u540c\u7684 MRSA \u5bb6\u65cf\u4e2d\uff0cCC398 \u662f\u4e00\u500b\u5f88\u6709\u4ee3\u8868\u6027\u7684\u4f8b\u5b50\u3002\u5b83\u6700\u65e9\u88ab\u6ce8\u610f\u5230\u6642\uff0c\u4e3b\u8981\u548c\u755c\u7267\u74b0\u5883\u6709\u95dc\uff0c\u56e0\u6b64\u9577\u671f\u88ab\u6b78\u985e\u70ba\u300c\u52d5\u7269\u76f8\u95dc\u578b MRSA\u300d\u3002\u5728\u9019\u6a23\u7684\u6846\u67b6\u4e0b\uff0c\u4eba\u985e\u611f\u67d3\u5e38\u88ab\u8996\u70ba\u5076\u767c\u4e8b\u4ef6\uff0c\u800c\u4e0d\u662f\u5b83\u7684\u4e3b\u8981\u751f\u614b\u4f4d\u3002<\/p>\n\n\n\n
\u9019\u500b\u7814\u7a76\u7684\u8d77\u9ede\u5176\u5be6\u5f88\u55ae\u7d14\u3002\u6211\u5011\u6574\u7406\u4e86\u53f0\u7063\u4e2d\u90e8\u5169\u5bb6\u91ab\u9662\u6536\u96c6\u7684 MRSA \u83cc\u682a\uff0c\u5728\u5176\u4e2d\u8fa8\u8b58\u51fa 14 \u682a\u5c6c\u65bc CC398 \u7684\u6848\u4f8b\u3002\u6578\u91cf\u4e0d\u591a\uff0c\u611f\u67d3\u578b\u614b\u4e5f\u4e0d\u7279\u5225\u6232\u5287\u5316\uff0c\u4f46\u6709\u4e00\u4ef6\u4e8b\u8b93\u4eba\u505c\u4e0b\u4f86\u60f3\u4e86\u4e00\u4e0b\uff1a\u9019\u4e9b\u75c5\u4eba\u90fd\u6c92\u6709\u660e\u78ba\u7684\u755c\u7267\u63a5\u89f8\u53f2\u3002\u5982\u679c CC398 \u4ecd\u7136\u4e3b\u8981\u4f86\u81ea\u52d5\u7269\uff0c\u90a3\u9019\u4e9b\u611f\u67d3\u662f\u600e\u9ebc\u767c\u751f\u7684\uff1f<\/p>\n\n\n\n
\u7b54\u6848\u4e26\u4e0d\u5728\u75c5\u6b77\u88e1\uff0c\u800c\u662f\u5728\u7d30\u83cc\u7684\u57fa\u56e0\u9ad4\u4e2d\u3002<\/p>\n\n\n\n
\u900f\u904e\u5168\u57fa\u56e0\u9ad4\u5b9a\u5e8f\uff0c\u6211\u5011\u628a\u9019 14 \u682a CC398 \u7684\u300c\u6574\u672c\u8aaa\u660e\u66f8\u300d\u6524\u958b\u4f86\u8b80\uff0c\u800c\u4e0d\u662f\u53ea\u7528\u5c11\u6578\u6a19\u8a18\u53bb\u5206\u985e\u5b83\u5011\u3002\u5f88\u5feb\u5c31\u53ef\u4ee5\u770b\u51fa\uff0c\u9019\u4e9b\u83cc\u682a\u5176\u5be6\u5206\u6210\u5169\u7fa4\u3002\u4e00\u7fa4\u662f ST398\uff0c\u6574\u9ad4\u6a23\u8c8c\u9084\u7b97\u63a5\u8fd1\u904e\u53bb\u5c0d CC398 \u7684\u7406\u89e3\uff0c\u4f46\u5df2\u7d93\u5e36\u6709\u4e00\u4e9b\u8207\u4eba\u985e\u514d\u75ab\u9003\u907f\u76f8\u95dc\u7684\u57fa\u56e0\uff0c\u986f\u793a\u5b83\u5011\u6b63\u5728\u5f80\u4eba\u985e\u9069\u61c9\u578b\u65b9\u5411\u79fb\u52d5\uff0c\u53ea\u662f\u4ecd\u4fdd\u6709\u76f8\u7576\u7a0b\u5ea6\u7684\u591a\u6a23\u6027\u3002<\/p>\n\n\n\n
\u53e6\u4e00\u7fa4\u5247\u662f ST1232\u3002\u9019\u4e00\u7fa4\u5728\u5206\u6790\u6642\u986f\u5f97\u975e\u5e38\u4e00\u81f4\uff1a\u5e7e\u4e4e\u90fd\u5e36\u6709\u8207\u56b4\u91cd\u76ae\u819a\u611f\u67d3\u76f8\u95dc\u7684 PVL \u6bd2\u7d20\uff0c\u5177\u5099\u5b8c\u6574\u7684\u4eba\u985e\u514d\u75ab\u9003\u907f\u57fa\u56e0\u7d44\u5408\uff0c\u5c0d\u591a\u7a2e\u6297\u751f\u7d20\u5177\u6709\u6297\u85e5\u6027\uff0c\u800c\u4e14\u5728\u6574\u500b\u57fa\u56e0\u9ad4\u7d50\u69cb\u4e0a\u9ad8\u5ea6\u76f8\u4f3c\u3002\u9019\u6a23\u7684\u7279\u5fb5\uff0c\u6bd4\u8f03\u4e0d\u50cf\u662f\u96f6\u661f\u51fa\u73fe\u7684\u8b8a\u7570\uff0c\u800c\u66f4\u50cf\u662f\u4e00\u500b\u5df2\u7d93\u5728\u7279\u5b9a\u74b0\u5883\u4e2d\u7a69\u5b9a\u5b58\u5728\u3001\u4e26\u4e14\u6301\u7e8c\u64f4\u6563\u7684\u65cf\u7fa4\u3002<\/p>\n\n\n\n
\u70ba\u4e86\u9032\u4e00\u6b65\u78ba\u8a8d\u9019\u500b\u5224\u65b7\uff0c\u6211\u5011\u628a\u53f0\u7063\u7684\u83cc\u682a\u653e\u9032\u570b\u969b\u8cc7\u6599\u5eab\u4e2d\u9032\u884c\u6bd4\u8f03\u3002\u7d50\u679c\u986f\u793a\uff0c\u53f0\u7063\u7684 ST1232 \u8207\u65e5\u672c\u3001\u97d3\u570b\u3001\u6fb3\u6d32\uff0c\u751a\u81f3\u90e8\u5206\u6b50\u6d32\u7684\u4eba\u985e\u611f\u67d3\u682a\u975e\u5e38\u63a5\u8fd1\u3002\u9019\u610f\u5473\u8457\uff0c\u5b83\u4e0d\u662f\u53f0\u7063\u7279\u6709\uff0c\u4e5f\u4e0d\u662f\u6700\u8fd1\u624d\u51fa\u73fe\u7684\u578b\u5225\uff0c\u800c\u662f\u4e00\u500b\u5df2\u7d93\u5728\u591a\u500b\u5730\u5340\u6210\u529f\u9069\u61c9\u4eba\u985e\u5bbf\u4e3b\u7684 MRSA \u652f\u7cfb\uff0c\u53ea\u662f\u6211\u5011\u73fe\u5728\u624d\u6bd4\u8f03\u6e05\u695a\u5730\u628a\u5b83\u8fa8\u8b58\u51fa\u4f86\u3002<\/p>\n\n\n\n
\u5f9e\u57fa\u56e0\u9ad4\u7684\u89d2\u5ea6\u4f86\u770b\uff0c\u9019\u6a23\u7684\u7d50\u679c\u4e26\u4e0d\u8b93\u4eba\u610f\u5916\u3002\u7d30\u83cc\u7576\u7136\u4e26\u4e0d\u53ef\u80fd\u5728\u610f\u6211\u5011\u5982\u4f55\u66ff\u5b83\u5011\u5206\u985e\uff0c\u5b83\u5011\u53ea\u662f\u5728\u4e0d\u540c\u5bbf\u4e3b\u8207\u74b0\u5883\u4e4b\u9593\u53cd\u8986\u79fb\u52d5\u3001\u8abf\u6574\u81ea\u5df1\u3002\u7576\u67d0\u4e00\u7a2e\u57fa\u56e0\u7d44\u5408\u771f\u7684\u6210\u529f\uff0c\u5b83\u5c31\u4e0d\u518d\u53ea\u662f\u8de8\u7269\u7a2e\u7684\u5076\u767c\u4e8b\u4ef6\uff0c\u800c\u6703\u6210\u70ba\u4e00\u500b\u80fd\u5728\u4eba\u7fa4\u4e2d\u7a69\u5b9a\u6d41\u52d5\u7684\u65cf\u7fa4\u3002\u9019\u6b63\u662f\u4eba\u755c\u5171\u540c\u5065\u5eb7\uff08One Health\uff09\u6982\u5ff5\u4e2d\u6700\u6838\u5fc3\u3001\u4f46\u4e5f\u6700\u5bb9\u6613\u88ab\u5ffd\u7565\u7684\u4e00\u9ede\u3002<\/p>\n\n\n\n
\u5728\u5206\u6790\u65b9\u6cd5\u4e0a\uff0c\u9019\u9805\u7814\u7a76\u4e26\u6c92\u6709\u4f9d\u8cf4\u4ec0\u9ebc\u7279\u5225\u82b1\u4fcf\u7684\u6280\u8853\uff0c\u800c\u662f\u5168\u9760\u6211\u5011\u5718\u968a\u6210\u54e1\u7684\u8010\u5fc3\u4e00\u6b65\u4e00\u6b65\u628a\u4e8b\u60c5\u770b\u6e05\u695a\u3002\u4e00\u65b9\u9762\uff0c\u6211\u5011\u6bd4\u8f03\u4e0d\u540c\u83cc\u682a\u5728\u300c\u57fa\u672c\u7d50\u69cb\u300d\u4e0a\u7684\u76f8\u4f3c\u7a0b\u5ea6\uff0c\u78ba\u8a8d\u5b83\u5011\u5728\u6574\u9ad4\u89aa\u7de3\u95dc\u4fc2\u4e2d\u7684\u4f4d\u7f6e\uff1b\u53e6\u4e00\u65b9\u9762\uff0c\u4e5f\u4ed4\u7d30\u6aa2\u8996\u90a3\u4e9b\u8f03\u70ba\u300c\u6d41\u52d5\u300d\u7684\u57fa\u56e0\u7247\u6bb5\uff0c\u4f8b\u5982\u8207\u6297\u85e5\u6027\u3001\u6bd2\u529b\u6216\u514d\u75ab\u9003\u907f\u76f8\u95dc\u7684\u57fa\u56e0\uff0c\u770b\u770b\u5b83\u5011\u662f\u5426\u4ee5\u56fa\u5b9a\u7684\u65b9\u5f0f\u88ab\u4fdd\u7559\u4e0b\u4f86\u3002\u7576\u4e00\u7fa4\u83cc\u682a\u4e0d\u53ea\u9aa8\u67b6\u76f8\u8fd1\uff0c\u9023\u9019\u4e9b\u529f\u80fd\u6027\u6a21\u7d44\u7684\u7d44\u5408\u8207\u4f4d\u7f6e\u90fd\u9ad8\u5ea6\u4e00\u81f4\u6642\uff0c\u901a\u5e38\u4ee3\u8868\u9019\u4e0d\u662f\u5076\u7136\uff0c\u800c\u662f\u4e00\u500b\u5df2\u7d93\u88ab\u81ea\u7136\u9078\u64c7\u7a69\u5b9a\u4fdd\u7559\u4e0b\u4f86\u7684\u578b\u614b\u3002<\/p>\n\n\n\n
\u5f9e\u9019\u500b\u89d2\u5ea6\u4f86\u770b\uff0c\u9019\u7bc7\u7814\u7a76\u7684\u91cd\u9ede\u5176\u5be6\u4e0d\u662f\u300c\u767c\u73fe\u4e86\u4e00\u7a2e\u65b0\u7684 MRSA\u300d\uff0c\u800c\u662f\u66f4\u52d9\u5be6\u5730\u88dc\u4e0a\u4e00\u584a\u62fc\u5716\uff1a\u5728\u53f0\u7063\uff0c\u78ba\u5be6\u53ef\u4ee5\u770b\u5230\u5df2\u7d93\u5b8c\u6210\u300c\u4eba\u985e\u9069\u61c9\u300d\u7684 CC398 \u652f\u7cfb\u5b58\u5728\u65bc\u81e8\u5e8a\u611f\u67d3\u4e4b\u4e2d\u3002\u5982\u679c\u4ecd\u7136\u53ea\u7528\u300c\u755c\u7267\u76f8\u95dc MRSA\u300d\u7684\u6846\u67b6\u4f86\u7406\u89e3 CC398\uff0c\u5f88\u5bb9\u6613\u4f4e\u4f30\u50cf ST1232 \u9019\u6a23\u7684\u65cf\u7fa4\u3002<\/p>\n\n\n\n
\u9019\u500b\u4e3b\u984c\u4e3b\u8981\u7531\u535a\u73ed\u751f\u5433\u5b97\u6a3a\u91ab\u5e2b\uff0c\u4ee5\u53ca\u5df2\u7d93\u7562\u696d\u7684\u78a9\u58eb\u751f\u5433\u8a60\u5a55\u4e00\u8d77\u5b8c\u6210\uff0c\u66f4\u65e9\u6211\u5011\u5718\u968a\u7684\u5e7e\u4f4d\u7562\u696d\u7684\u78a9\u73ed\u751f\u674e\u67d4\u8351\u3001\u842c\u7f8e\u79c0\u3001\u8449\u6587\u76db\u4e5f\u53c3\u8207\u4e26\u5148\u5f8c\u63d0\u4f9b\u4e86\u5354\u52a9\u3002\u5c0d\u6211\u5011\u5718\u968a\u800c\u8a00\uff0c\u9019\u4e26\u4e0d\u662f\u4e00\u500b\u8ffd\u6c42\u6232\u5287\u6548\u679c\u7684\u984c\u76ee\uff0c\u800c\u662f\u5927\u91cf\u5b9a\u5e8f\u3001\u6bd4\u5c0d\u8207\u53cd\u8986\u78ba\u8a8d\u7684\u904e\u7a0b\u3002\u67d0\u7a2e\u7a0b\u5ea6\u4e0a\uff0c\u6211\u5011\u5718\u968a\u7684\u7814\u7a76\u751f\u5011\u5728\u9019\u88e1\u505a\u7684\u4e8b\u60c5\uff0c\u5c31\u662f\u628a\u539f\u672c\u6709\u9ede\u6a21\u7cca\u7684\u8f2a\u5ed3\uff0c\u4e00\u9ede\u4e00\u9ede\u63cf\u6e05\u695a\uff0c\u8b93\u6211\u5011\u5728\u8a0e\u8ad6 MRSA \u8207\u4eba\u755c\u5171\u540c\u611f\u67d3\u6642\uff0c\u591a\u4e86\u4e00\u4efd\u4f86\u81ea\u57fa\u56e0\u9ad4\u5c64\u7d1a\u7684\u5be6\u8b49\u4f9d\u64da\u3002<\/p>\n\n\n\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
Genomic and phylogenetic characterization of human-adapted methicillin-resistant\u00a0Staphylococcus aureus\u00a0clonal complex 398 lineages in Taiwan Microbiology Spectrum https:\/\/doi.org\/10.1128\/spectrum.02090-25 \u5176\u5be6\u5728\u81e8\u5e8a\u4e0a\u8ac7\u5230 MRSA\uff0c\u591a\u534a\u9084\u662f\u628a\u5b83\u7576\u6210\u4e00\u500b\u300c\u6297\u85e5\u6027\u5f88\u9ebb\u7169\u7684\u7d30\u83cc\u300d\u4f86\u7406\u89e3\u3002\u4f46\u5982\u679c\u628a\u6642\u9593\u62c9\u9577\u4f86\u770b\uff0cMRSA \u5f9e\u4f86\u5c31\u4e0d\u53ea\u662f\u91ab\u9662\u88e1\u7684\u554f\u984c\uff0c\u5b83\u4e00\u76f4\u5728\u4e0d\u540c\u74b0\u5883\u4e4b\u9593\u6d41\u52d5\uff0c\u4e5f\u5728\u4e0d\u540c\u5bbf\u4e3b\u4e4b\u9593\u5617\u8a66\u9069\u61c9\u3002 \u5728\u958b\u59cb\u8ac7\u9019\u9805\u7814\u7a76\u4e4b\u524d\uff0c\u6216\u8a31\u9084\u662f\u9700\u8981\u5148\u7c21\u55ae\u8aaa\u660e\u4e00\u4e0b\uff0c\u4ec0\u9ebc\u662f<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"colormag_page_container_layout":"default_layout","colormag_page_sidebar_layout":"default_layout","footnotes":""},"categories":[5,40],"tags":[113,145,77,14,144,20,147,146],"class_list":["post-2108","post","type-post","status-publish","format-standard","hentry","category-blog","category-research","tag-bacterial-genomics","tag-cc398","tag-comparative-genomic-analysis","tag-genomics","tag-mrsa","tag-nanopore","tag-one-health","tag-st1232"],"_links":{"self":[{"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2108","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2108"}],"version-history":[{"count":2,"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2108\/revisions"}],"predecessor-version":[{"id":2110,"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2108\/revisions\/2110"}],"wp:attachment":[{"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2108"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2108"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/megagenome.nchu.edu.tw\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2108"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}