Welcome
About us
The Microbial Genomics Laboratory at the Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University, is dedicated to understanding how microbes evolve, adapt, and impact human, animal, and environmental health.
Our research focuses on antimicrobial resistance, pathogen virulence, outbreak transmission, and host-associated microbial interactions. By integrating genome sequencing, bioinformatics, comparative genomics, and functional experiments, we investigate how microbial traits emerge, spread, and can be controlled.
Current projects include bacterial plasmid biology, emerging hospital pathogens, foodborne bacteria, and endosymbiotic microbes such as Wolbachia for vector control applications.
We provide interdisciplinary training for students in genomics, microbiology, computational biology, and scientific communication. We welcome motivated students and collaborators who are interested in solving real-world biological challenges through modern genomic science.
關於我們
國立中興大學生命科學院基因體暨生物資訊研究所微生物基因體研究室，致力於探討微生物如何演化、適應環境，並影響人類健康、動物健康與環境安全。
本研究室主要研究抗菌抗藥性、病原菌毒力、群聚感染傳播，以及宿主相關微生物互動機制。我們整合基因體定序、生物資訊分析、比較基因體學與功能性實驗，解析微生物關鍵性狀如何形成、擴散與被控制。
目前研究主題包括細菌質體生物學、新興院內感染病原體、食品相關病原菌，以及Wolbachia等共生菌在病媒控制上的應用。
研究室提供跨領域訓練，培養學生在基因體學、微生物學、生物資訊與科學溝通等能力，歡迎對研究充滿熱情的學生與合作夥伴加入我們。
Research Themes
1. Antimicrobial Resistance and Mobile Genetic Elements
We investigate how plasmids, integrative elements, and regulatory genes drive the emergence and spread of antimicrobial resistance. Our work focuses on the evolution of transferable resistance determinants and their impact on bacterial fitness and pathogenicity.
2. Emerging Pathogens and Outbreak Genomics
Using whole-genome sequencing and comparative genomics, we study the transmission, adaptation, and persistence of clinically important pathogens, including hospital-associated outbreaks and newly emerging bacterial lineages.
3. Host–Microbe Interactions and Functional Regulation
We explore how microbes regulate virulence, stress responses, and host adaptation through transcriptional networks, mobile regulators, and genome plasticity.
4. Symbiotic Microbes and Vector Control Genomics
We develop genomic tools to study endosymbiotic bacteria such as Wolbachia, with applications in mosquito biology, disease control, and microbial ecology.
研究主題
1. 抗菌抗藥性與可移動遺傳元件
研究質體、整合型遺傳元件與調控基因如何促進抗藥性的形成與擴散，並探討其對細菌適應力與致病性的影響。
2. 新興病原體與群聚感染基因體學
利用全基因體定序與比較基因體學，解析重要病原菌的傳播途徑、環境適應與院內感染群聚事件。
3. 宿主互動與功能調控機制
探討細菌如何透過轉錄調控網絡、移動型調節因子與基因體可塑性，調節毒力、壓力反應與宿主適應能力。
4. 共生微生物與病媒控制基因體學
開發新型基因體工具研究Wolbachia等共生菌，應用於病媒蚊生物學、疾病控制與微生態研究。
Why Join Us
Joining our laboratory means becoming part of an interdisciplinary research environment where biology meets data science.
Students in our lab receive hands-on training in genome sequencing, bioinformatics, microbiology, scientific writing, and independent research design. Projects are closely connected to real-world challenges such as antimicrobial resistance, hospital outbreaks, food safety, and emerging infectious diseases.
We welcome students from diverse academic backgrounds. Whether your strength is biology, coding, statistics, or laboratory work, you will have opportunities to develop new skills and build a strong research portfolio.
Our goal is not only to help students complete a degree, but to train them to become confident scientists capable of solving important biological problems.
Many of our students have co-authored SCI publications and continued to careers in academia, biotechnology, healthcare, and data science.
為什麼加入我們？
加入本研究室，代表你將進入一個結合生命科學與資料科學的跨領域研究環境。
學生將接受完整訓練，包括基因體定序、生物資訊分析、微生物實驗、科學論文寫作，以及獨立研究能力的培養。研究題目緊密連結真實世界挑戰，例如抗藥菌、院內感染、食品安全與新興傳染病等重要議題。
我們歡迎不同背景的學生加入。無論你擅長生物實驗、程式分析、統計思維，或希望學習新的研究技能，都能在研究室中找到成長方向。
我們的目標不只是協助學生完成學位，更希望培養具備思辨能力、研究能力與解決問題能力的下一代科學人才。
許多學生在學期間參與 SCI 論文發表，並持續發展於學術研究、生技產業、醫療體系與資料科學領域。